How to Block Maleria Transmission in your region

MALERIA TRANSMISSION LIFE CYCLE

Maleria transmission within the human body happens in a full circle. It can be by two phases. One is asexual phase and another is sexual phase. Asexual phase uses the human body as the host. The sexual phase of lifecycle happens within a mosquito. The details below can be referred to learn more about the cycle.

The asexual phase of the lifecycle of Meleria in the human body starts with the inoculation of the parasite into the human blood by the Anopheles mosquito. The sporozoites reach the liver and start invading the liver cells.

The trophozoites start their intracellular asexual division within the liver cells. Thousands of extra erythrocyctic merozoites are released from each liver cell at the completion of this phase. The time for the completion of tissue phase differs with the infecting species. This interval is called as pre-patent period.

The merozoites enter the red blood cell by a process of invagination where the asexual division starts and the parasites develop through the stages of rings, trophozoites, early schizonts and mature schizonts. These contain thousands of erythrocytic merozoites which are released by the RBC and it invades uninfected red cells. This cycle of invasion- multiplication – release-invasion repeats. A small proportion of the merozoites in the red blood cells undergo transformation into male and female gametocytes. Mature gametocytes appear in the blood and enter the mosquito when it bites an individual with infection.

The sexual phase happens in the mosquito when the gametocytes continue their development. The male and female gametes fuse and form a zygote. This transforms into an oocyst which divides asexually into sporozoites and reach the salivary gland of the mosquito which are inoculated into human blood stream. Thus it becomes a full cycle.